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doi: 10.1016/0891-5849(92)90147-9

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In humans, eight distinct glutathione peroxidase isoforms (GPX1GPX8) have been identified

In accordance, other authors have shown that induction of HO-1 in macrophages strongly promotes anti-inflammatory activity [54]

However, bioavailability issues, lack of clinical standardization, and insufficient large-scale trials remain key obstacles that must be addressed before natural compounds can be integrated into mainstream AD therapy