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According to the mechanism study, baicalein could downregulate downstream important glycolytic enzymes (HK2, LDH-A, PDK1) by encouraging the accumulation of intracellular PTEN and inhibiting the activation of the PI3K/Akt signaling, thereby reversing the hypoxia-induced 5-Fu resistance (115)

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However, in this case, comparisons with our data (Fortier and Matte, 2006) are difficult, because the treatments were initiated late in gestation (from 60 days) and unfortunately, no data were reported on GSH-Px in sows

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