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Since reperfusion used to treat IS causes additional damage in brain cells, including the accumulation of excess oxygen radicals and activation of apoptosis, the discovered therapeutic effects of ACTH(69)PGP allow us to highly appreciate the possibility of its clinical use after the administration of thrombolytics (e.g., tPA) or mechanical thrombectomy

14 As hypomagnesaemia is commonly associated with other metabolic abnormalities, in particular, hypokalaemia, hypocalcaemia and metabolic acidosis, it is difficult to determine which symptoms are solely due to the hypomagnesaemia

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This is one of the key drivers of mitochondrial failure, accumulation of irreparable DNA damage and cellular aging across tissues