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This approach makes it possible to detail the changes in gene expression during the development of IS in order to identify the signaling pathways involved in the molecular mechanisms of damage

Aging Pathobiology and Therapeutics

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Note the confluence of drugs working on the growth hormone axis in this Table and the one above

The initial dosing protocol starts with tirzepatide 2.5 mg weekly plus cagrilintide 0.3 mg weekly, with gradual escalation over several weeks to minimize side effects