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In practice, exogenous follistatin delivery is not currently clinically feasible the molecule doesn't survive oral administration, injectable forms have short half-lives, and there is no approved delivery system

In addition, ROS can activate the expression of the nuclear transcription factorkappa, which upregulates the expression of many genes involved in MS, such as tumor necrosis factor and nitric oxide synthase, among others, leading to mitochondrial dysfunction and energy deficits that result in mitochondrial and cellular calcium overload

CNS 16, 15

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