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Furthermore, target individual cytokines (anti-IL-1 glucocorticoids, anti-IL-6 simvastatin/haritaki) and small molecules that modulate upstream regulators such as p53 (nutlin-3a) or inhibit LINE-1-driven inflammatory signaling (nucleoside reverse transcriptase inhibitors like lamivudine) also function as SASP inhibitors

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These findings suggest that organic acids may offer therapeutic benefits for severe thyroid inflammation