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Curcumin, a polyphenol derived from C

We found the most evident maintenance of GPX4 in the Glu- or erastin-induced HT22 cell injury model after pretreatment with lapatinib

Moran C, Sanz-Rodriguez A, Jimenez-Pacheco A, Martinez-Villareal J, McKiernan RC, Jimenez-Mateos EM, et al

Based on the current evidence, we propose that the iron-overloaded, ROS-prone milieu of EMS renders EESCs susceptible to Erastin-triggered, multi-pathway regulated cell death that integrates ferroptosis with necroptotic and pyroptotic signaling, while ferritin handling and mitophagy act as key modulators of susceptibility