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Damage-associated molecular patterns (DAMPs) are of particular interest, as they can trigger the inflammatory response observed in the active stage of vitiligo, with a series of DAMP-associated proteins existing in vitiligo.4 The DAMP with the most evidence of association with vitiligo is heat shock protein 70 (HSP70), which belongs to the family of intracellular chaperones whose function is to prevent incorrect protein folding
Nature 355(6359):441446 Zheng J-N, Zhuo J-Y, Nie J, Liu Y-L, Chen B-Y, Wu A-Z, Li Y-C (2021) Phenylethanoid glycosides from Callicarpa kwangtungensis Chun attenuate TNF--induced cell damage by inhibiting NF-B pathway and enhancing Nrf2 pathway in A549 cells
substitution with other residues dramatically reduces copper-binding affinity and alters the complex's properties
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