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In particular, germinal center (GC) B cells, composed of activated B cells, abundantly produced intracellular ROS, which was further elevated by LBI feeding (Fig

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doi: 10.3389/fpls.2014.00662 Received 26 September 2014 Accepted 06 November 2014 Published 21 November 2014 Volume 5 - 2014 Edited by Dibyendu Talukdar, Raja Peary Mohan College (Affiliated to University of Calcutta), India Reviewed by Dibyendu Talukdar, Raja Peary Mohan College (Affiliated to University of Calcutta), India

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It is known that, in rat and human GLCL holoenzyme, cystamine completely inactivates rat GLCL activity by interaction with a thiol group that is thought to be at or near the l-glutamate-binding site in the wild enzyme [135,136,137,138] and also in a recombinant mutant (hGLCLC-C553G) where one cysteine group far from the active site was selectively inactivated [139]

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