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This process is initiated by Fe 2+ -catalyzed lipid peroxidation process through non-enzymatic (Fenton reaction) and enzymatic mechanisms (lipoxygenase) [221]

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4a, the G/D-CuP group exhibited the most intense CD206-associated red fluorescence signal among all treatment groups, indicating that G/D-CuP promotes macrophage polarization toward the M2 phenotype

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The Phase 3 REDEFINE program in adults with overweight or obesity was subsequently reported in the New England Journal of Medicine in 2025