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It is noteworthy that -Syn is also localized in mitochondria-associated endoplasmic reticulum membranes (MAMs), which are contact sites between two organelles, the mitochondria and the endoplasmic reticulum (Guardia-Laguarta et al., 2014)

HCV-induced ROS play a significant role in HCV pathogenesis, as Kupffer cell activation contributes to pro-fibrotic cytokine and ROS production, leading to hepatic damage 91,92

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