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Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals

Oxidants, antioxidants and the pathogenesis of emphysema

Vitamin B-12 deficiency in the elderly: current dilemmas

Through antioxidant enzyme systems such as Sod/Cat and stress pathways such as Hog1/TOR, it coordinates morphological transitions and metabolic remodeling to resist host immune killing and tolerate microenvironmental stress (Fleck et al., 2011)