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Our model supports regulation of all collaborating metabolic organs through changes in circulating redox metabolites, regardless of whether change was initiated exogenously or by a single organ

doi:10.1016/j.cmet.2018.06.008 2

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Notably, mitochondria play a pivotal role in regulating calcium homeostasis in oocytes, particularly during fertilization, by modulating calcium store release to initiate the cortical granule reaction and prevent polyspermy [36,37,38]