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It's also necessary for cellular metabolism and the metabolism of amino acids and fatty acids

That is a consistent pattern of failure to demonstrate the primary endpoint: significant fat reduction in humans

Vitamin B12 is also needed to help prevent megaloblastic anemia, which is a blood condition that often makes individuals tired and weak

Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

However, side effects can occur, although they are rare