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48, 49 However, claudin-2 also serves other diverse functions including paracellular passage of cations (including sodium and calcium), cell proliferation and autophagy, and loss of claudin-2 along with claudin-15, yet another TJ protein implicated in paracellular Na + passage, results in premature death because of malnourishment in mice

So for chronic degenerative conditions, my bias is to avoid it, and my bias strengthens the longer someone wants to use it

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Bioinformatics 31: 32223224 van Zundert GC, Trellet M, Schaarschmidt J, Kurkcuoglu Z, David M, Verlato M, Rosato A, Bonvin AM (2017) The DisVis and PowerFit web servers: explorative and integrative modeling of biomolecular complexes

42 KomatsuM.KurokawaH.WaguriS.TaguchiK.KobayashiA.IchimuraY.et al (2010)