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The heme group of enzymes is very important for endothelial cells because it regulates activities of soluble guanylate cyclases (GCs), nitric oxide synthase (NOS), cytochrome P450 (CYP450), mono-oxigenase, cyclo-oxigenase (COX) and catalase (21, 22)

Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, Duvic M, King LE, Jr., McMichael AJ, Randall VA, Turner ML, Sperling L, Whiting DA, Norris D, National Alopecia Areata F (2004) Alopecia areata investigational assessment guidelines--part II

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