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Bloodbrain barrier breakdown in the aging human hippocampus

It is important to acknowledge that the relationships we found between AC levels, MDD diagnosis, depression severity and depression profiles may be explained to some extent by shared distal environmental and lifestyle factors (e.g., comorbid somatic diseases, sedentary behavior, smoking, high-fat diet, alcohol consumption [61,62,63,64] that could act as confounder or mediators of the association

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This review primarily aims to explore the combined effects of polyphenol supplementation and exercise on depression and brain health parameters