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Lower NP concentrations promoted the proliferation of chondrocytes, which is consistent with previous observations that Cu ions and Cu-based nanomaterials can accelerate cell proliferation by enhancing the synthesis of insulin-like growth factor 1 [52]

They face distinct health challenges throughout their lives, from adolescence to healthy ageing

5 , e888 (2022)

Acetylcholine (ACh) released from neurons activates muscarinic ACh receptors (MRs) on ECs, increasing nitric oxide (NO) production, EC hyperpolarization, and consequently, elevated CBF [92]

508,509,510,511 Additionally, GLP-1 mitigates liver inflammation and fibrosis by inhibiting the NF-B pathway, reducing the release of pro-inflammatory cytokines such as TNF- and IL-6, and thus suppressing inflammatory pathways