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A convenience sample of children diagnosed with a precursor to hypermobile EDS at a tertiary hospital who were followed for three years found four factors that predicted disease severity and modestly predicted development of disability over time: multisystem involvement, pain, fatigue, and postural control

Consistency is more important than timing

Park Y, Ziegler TR, Gletsu-Miller N, Liang Y, Yu T, Accardi CJ, Jones DP

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The CJC-1295 and Ipamorelin stack is the stronger modern option more injections per day, larger growth-hormone pulse, more pronounced effects on body composition and recovery