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The overall risk appears to be very low, but the theoretical concern necessitates appropriate patient selection and informed consent

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Effects appear within days of starting treatment and accumulate with continued use

Research and Future Directions The future of methylene blue research is promising, with ongoing studies exploring new medical applications and innovative uses

4 Other trials on NAD+ for addiction typically had patients use 500-1000mg of NAD+ in 300mL of normal saline typically with a loading period of daily dosing for four days, followed by a taper period of twice weekly dosing for a month, and finally reducing to just twice monthly dosing until resolution of addiction