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Particle size reduction techniques include, by way of example, grinding, milling (e.g., air-attrition milling (jet milling), ball milling), coacervation, high pressure homogenization, spray drying and/or supercritical fluid crystallization

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Animal model SpragueDawley rats (68 weeks, 180230 g) obtained from Guangdong Vital River Laboratory Animal Technology Co., Ltd