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Senkyunolides are, in fact, important metabolites derived from ligustilide, undergoing biotransformationcatalyzed by NADPH-dependent monooxygenasesinto compounds such as senkyunolide H and I ( in vivo , a factor that directly governs their systemic bioavailability and resultant pharmacological activity

Hamed KM, Dighriri IM, Baomar AF, Alharthy BT, Alenazi FE, Alali GH, Alenazy RH, Alhumaidi NT, Alhulayfi DH, Alotaibi YB, Alhumaidan SS, Alzahrani SA, Alobaid RH (2022) Overview of methotrexate toxicity: a comprehensive literature review

This regulatory status reflects the absence of completed human clinical trials establishing safety and efficacy to approval standards

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