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Future development must directly address these concerns

4.1 Antifungal drugs targeting the cell wall Recent advances in antifungal therapy have introduced new agents targeting the fungal cell wall, notably Ibrexafungerp and Rezafungin, both of which have shown promising results in clinical trials against Candida albicans , Candida auris , and Aspergillus spp (Spec et al., 2019

DSIP readily crosses the blood-brain barrier to exert central effects and may enhance inhibitory neuronal activity or modulate sleep-regulating brain regions

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