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Nakase T, Yamazaki T, Ogura N, Suzuki A, Nagata K

412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1

Its mechanism of action remains an active area of investigation, with researchers exploring interactions between this peptide and multiple signaling networks involved in cellular repair and cytoprotection

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This means the inflammation never completely resolves and can flare up periodically