preclinical safety evaluation found no genotoxicity, mutagenicity, or organ toxicity at tested doses
Pintore A, Notarfrancesco D, Zara A, et al
DOI: 10.1158/1055-9965.EPI-17-1136 Morales-Gutierrez J et al, "Toxicity induced by multiple high doses of vitamin B 12 during pernicious anemia treatment: a case report." Clinical Toxicology, Feb
Several research questions remain open
NAD + metabolism in neurodegenerative disorders Neurodegenerative diseases are a heterogeneous group of diseases, including Alzheimers disease (AD), Parkinsons disease (PD) and amyotrophic lateral sclerosis (ALS), which are characterized by progressive degeneration of the structure and function of the peripheral and central nervous system, with the characteristics like the accumulation of misfolded and aggregated proteins that are associated with severe proteotoxic stress (Fig