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Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur

Antibodies to intrinsic factor (IF) bind to IF and prevent formation of the IF-B 12 complex, further inhibiting vitamin B 12 absorption

If a blood test confirms that your B12 levels are low, supplementing can get your levels of the nutrient back to normal and help you feel more energized

It is contraindicated in patients with uncontrolled hypertension, cardiovascular disease, or who are using MAOIs