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10.1016/j.bioorg.2021.105329 193 MartinelloM.MutinelliF
These overall immunological responses contribute to the enlargement and overgrowth of the synovial lining, destruction of cartilage, formation of osteoclasts, synovial inflammation, pain, and an elevated risk of neoplastic infections [12]
Gastrointestinal symptoms: Some peptides, especially GLP-1 receptor agonists such as semaglutide or tirzepatide, can slow digestion, which may lead to nausea, vomiting, diarrhea, or constipation
There is no cure available
In summary, the particle size appears to be a critical factor influencing the biological response of blood and immune cells to PET exposure, with NPs ( 200 nm) generally exhibiting higher toxicity compared to larger MPs
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