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TNF- also synergizes with IFN- to simulate the production of reactive nitrogen intermediates for mycobacterial killing within macrophages ( Our preclinical studies confirmed the previous findings that the T2DM group has lower levels of IFN- ( Figure 3E ) and TNF- ( Figure 3F ) when compared to healthy individuals

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Intratumoral or local administration increases regional exposure and spatial control, especially for immune agonists, photothermal or photodynamic constructs and locally activated theranostic systems

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Nonetheless, the precise mechanisms of zonulin receptor binding remain incompletely understood and is an area in need of additional study