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GPX4 is an antioxidant enzyme that detoxifies lipid hydroperoxides using GSH as a co-factor [16,54] and GCLC is a subunit of heterodimeric GSH biosynthetic enzyme [55]

Regulation of cell proliferation and apoptosis: Glutathione depletion is a signal for apoptosis (programmed cell death), while adequate levels support normal cell proliferation [2][5]

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