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Reid et al., 2023

23, 255264, e119

Retatrutide Dosage Protocols from Clinical Trials Phase 2 clinical trials published in The New England Journal of Medicine in 2023 established the foundational retatrutide dosage framework [6]: Standard Retatrutide Dosing Schedule: 4 mg weekly Lower effective dose with moderate efficacy 8 mg weekly Mid-range dose with enhanced metabolic effects 12 mg weekly Maximum studied dose achieving 24.2% mean weight reduction The 12 mg dose demonstrated the most significant metabolic effects but also carried the highest incidence of gastrointestinal adverse events, with nausea reported in 60-80% of participants [7]

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Before use, may be stored at room temperature (up to 86F/30C) for up to 21 days Exenatide extended-release (Bydureon BCise) : Single-dose autoinjector