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Materials and Methods This scoping review was conducted according to the 5 stage methodology described by Khalil and colleagues (2016)

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10.1371/journal.pone.0034776 112 MiquelE.CassinaA.Martnez-PalmaL.SouzaJ

In normal cases, PINK1 is degraded by healthy mitochondria, but when mitochondria become dysfunctional or damaged, PINK1 accumulates on their outer membranes, recruiting Parkin to mark the defective organelles for autophagic degradation