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It should be kept away from strong chelators (such as high levels of EDTA and related sequestrants), reducing sugars, thiol-bearing actives, and high concentrations of direct acids (for example ascorbic acid or alpha-hydroxy acids at low pH), all of which can compete for the copper center or disrupt the peptide-metal bond and shift the characteristic blue color toward brown or colorless degradation products

However, as with any emerging compound, rigorous research and ethical use are paramount

The process works like this: the FDAs Pharmacy Compounding Advisory Committee (PCAC) must review each substance and make a recommendation

GHK-Cu Acetate Suggested directions GHK-Cu Troche Dissolve one troche sublingually or between gum and cheek one time daily This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient

Immunogenicity: Peptides can trigger immune responses, including the formation of anti-drug antibodies