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Innate immune gene upregulation is a conserved response to chronic nicotine Since the effects of chronic nicotine were broad, affecting multiple cell types, we investigated potential mechanisms responsible for the aggressive properties of cNic cells by performing GSEA analysis on the overall differentially-expressed genes (DEG)

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F10.239 Alcohol use disorder with withdrawal, unspecified F11.21 Opioid dependence with withdrawal F12.288 Cannabis use disorder with other specified effects Common Challenges in ICD-10 Coding for Substance Use Disorders Complexity of Diagnosis: Substance use disorders often present with complex symptomatology and co-occurring mental health issues

DOI: 10.3389/fmolb.2020.00133 Funding: National Science Foundation, ARCS Foundation, Anne and Russ Fuller Fellowship for Interdisciplinary Research, USDA National Institute of Food and Agriculture This story was first published by the University of Chicago Medicine.