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Moreover, it was demonstrated that T-2 toxin induced cytotoxicity in HeLa cells is mediated by generation of ROS leading to DNA damage and trans activation of p53 protein expression which leads to shift in the ratio of Bax/Bcl-2 in favour of apoptosis and subsequent release of Cyt-c from mitochondria followed by caspase cascade [99]

According to one embodiment, the therapeutic amount of the Centella asiatica (Gotu kola) extract is from about 100 mg to about 3,000 mg for daily administration