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Tie-2 is the tyrosine kinase receptor for Ang-1 and Ang-2, molecules that regulate angiogenesis and endothelial cell survival, proliferation and migration (73)

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Incidentally, the healthy reference range is 191-663 pg/ml and correlates closely with oral cobalamin intake, which is why the vitamin B12 blood level alone is not an adequate parameter to diagnose a deficiency (Herrmann and Obeid, 2014)

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PMID: 40010607 J Adv ResOdontogenic exosomes simulating the developmental microenvironment promote complete regeneration of pulp-dentin complex in vivo