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Nicotine self-Administration in Animals as a dependence model

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Conducting additional experiments with RPE cells donated by two people without age-related macular degeneration, or AMD, who did not smoke, one person without AMD who smoked, and one person with early AMD, the researchers identified 1,698 genes that either increased or decreased in expression and were shared between dysfunctional human and mouse RPE cells

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Int J Epidemiol, 2016

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the smoking article includes a lighting end (i.e., an upstream end) and a mouth end (i.e., a downstream end)

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