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Description

Over time, they can release inflammatory signals (often called the SASP, or senescence-associated secretory phenotype) that may contribute to tissue dysfunction seen with aging and some age-related conditions

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Injection site redness and itching can signal that degradation products are triggering a local inflammatory response

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Behavior Illustrative animal behavior on days and weeks after retrobulbar application of L-NAME when mounted on an elevated surface was that rats maintained the initial position of firmly standing on to the surface with posterior legs, almost frozen, with limited movements only (Figure 8, Figure 9)

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Weekly dosing means a 3mg vial provides multiple weeks of treatment at lower doses

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& Protzer, U

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