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If you are self-supplementing with high-dose B12 without medical indication, discuss this with your GP

GHK-Cu has preclinical + clinical (topical)

Major Criteria Skin hyperextensibility, with velvety skin texture and absence of atrophic scarring Generalized joint hypermobility, with or without recurrent dislocations (most commonly shoulder and ankle) Easily bruisable skin/spontaneous ecchymoses Minor Criteria Foot deformities (broad/plump forefoot

Maintaining healthy levels of the nutrient may also decrease inflammation-induced semen impairment, according to researchers

For cardiovascular goals specifically, community wisdom suggests starting at the lower end of the dosage range