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Clinically, voxelotor should only be used during pregnancy if the benefits outweigh the risks, as the drug could harm both the fetus and the mother

Glutathione-S-transferase and glutathione peroxidase activity measurements Brains were extracted and immersed in ice-cold Ca- and Mg-supplemented PBS for sampling of lateral and fourth ventricle choroid plexuses under a stereomicroscope

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Although most of these data were generated in regenerative settings rather than during steady-state aging, they support a model in which aging can reduce the MuSC pool through probabilistic loss or dysfunction of MuSCs (or labeled lineages) without implying deterministic, subset-specific collapse of heterogeneity (Fig