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Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]

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Petris MJ, Voskoboinik I, Cater M, Smith K, Kim BE, Llanos RM, et al

doi: 10.1038/nrneurol.2017.139 249