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Toxicology and carcinogenicity studies of diuretics in F344 rats and B6C3F1 mice

Nuclear membrane lipid peroxidation products bind to nuclear macromolecules

To identify the proteins present, database searches of the extracted proteins unambiguously identified the 200 kDa protein and 100 kDa proteins in non-reduced and reduced samples, respectively, as transferrin receptor 1 (TfR1, gene name TFRC), a 200-180 kDa homo-dimeric, disulfide-linked protein

H., Pickersgill, N

This is important in the case of analysis of biological samples, where as a rule large excesses of reducing agents are used to break all disulfide bonds