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Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme essential for cellular energy production and DNA repair

Fertility and Sterility, 103(3), 522-528

Although much of the evidence described above come from cellular fractionation studies that will need validation, these findings may explain the mitochondrial dysfunction reported in in vitro and in vivo SCA3 models, namely mtDNA deletions and reduced copy number that are often found in SCA3 cells, transgenic mice, and patients

These findings are supported by multiple rodent studies showing enhanced biomechanical strength and collagen organization in repaired tendons

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