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Potential Side Effects Water retention (GH-related peptides) Joint stiffness or tingling (GH-related peptides) Lethargy (in some sensitive users) Increased appetite (MK-677 in particular) Injection site irritation (rare with proper technique) Legal Disclaimer Peptides such as BPC-157, TB500, and various growth hormone secretagogues are not approved by the FDA for general performance or cosmetic use

More recently, analysis using the Broad Institutes Connectivity Map database identified GHK as one of the top two compounds (from 1,309 bioactive molecules screened) recommended for study in aggressive metastatic colon cancer models, with GHK upregulating expression of numerous caspase genes and DNA repair genes associated with anti-cancer activity