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Because vitamin (especially folate) supplementation can efficiently reduce plasma homocysteine levels, further prospective cohort studies and ongoing, randomized, placebo-controlled trials will determine the efficiency of folate supplementation, possibly in combination with vitamins B 12 and B 6 , in the prevention and correction of vascular disorders related to moderate hyperhomocysteinemia

The live probiotics are generally more effective than heat-killed preparations for mechanisms requiring metabolic activity (e.g., SCFA production, immune modulation), although toxin binding may persist after heat inactivation (98)

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