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It is generally believed that the observed mitochondria-related cytoplasmic vesicles result from the lysosomal apoptotic pathway mediated by mitochondria.35 The formed vesicles might also be autophagosomes of mitochondrial origin, which after maturation, fuse with lysosomes.36 It is of note that a similar preferential intracellular co-localization phenomenon was described for phtalo-cyanine, a related porphyrin-like molecule.37 This data are also in line with the results of the functional studies

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Unlike many peptides that are rapidly degraded in the gut, Dihexas structural modifications allow it to survive digestive enzymes and maintain activity following oral administration in rodent models

Schousboe A, Apreza CL, Pasantes-Morales H