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Expected Physiological Responses The primary expected response to Ipamorelin administration is increased growth hormone secretion

The immunological response is hence unique and unpredictable (88, 241)

FIGURE 3 NO in cartilage and synovium is produced by iNOS, which mediates the expression of inflammatory factors, inhibits the synthesis of collagen and proteoglycan, and induces chondrocyte apoptosis and pain (Suantawee et al., 2015)

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Twice-daily administration would increase total daily receptor activation without providing additional time for structural consolidation, potentially accelerating receptor desensitization without proportional benefit