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it may damage the cells and tight junctions of the BBB [18] Homocysteine : High levels of homocysteine alter tight junction function and cause BBB dysfunction [19] Excess glutamate : Overstimulation of glutamate receptors in the brain may cause BBB breakdown

What We Know So Far: Tissue repair: Preclinical studies show accelerated healing of tendons, ligaments, and muscle through enhanced angiogenesis ( VEGF), collagen synthesis, and fibroblast activity

CTCs show significantly increased tumorigenicity and metastatic potential in a novel orthotopic syngeneic model of metastatic cancer [52]

Improvements were also seen in blood pressure, glycemic parameters, and physical function