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In recent years, small molecule antagonists, antisense oligonucleotides, and monoclonal antibodies targeting GCGR have been developed and demonstrated efficacy in improving glycemic control in both rodent models of diabetes and human patients with diabetes 8,9,10,11,12,13

Proc Am Soc Clin Oncol 18:421, 1999

In laboratory and pre-clinical settings, DSIP has been studied as a uniquely multifunctional endogenous regulatory neuropeptide across sleep, stress, neuroendocrine, neuroprotection, and geroprotective research applications: Sleep biology delta-wave SWS promotion, sleep homeostasis modulation, sleep efficiency and sleep latency research Sleep EEG research delta-wave induction, SWS vs REM sleep architecture, and sleep stage analysis via polysomnography Sleep neuromodulator pharmacology DSIP vs sedatives and hypnotics

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