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Oxidative medicine and cellular longevity
PLR is regulated, in part, by uncoupling proteins which are an integral part of the inner mitochondrial membrane
The shared host-cell adhesion and haem-binding functionality of many NTHi proteins suggests that bacterial haem-utilisation plays an important role in its interplay with host epithelial cells and may provide an adaptive advantage for colonisation in environments with low haem-iron availability ( 4.2 Survivability and virulence in the respiratory tract Continued NTHi survival in the respiratory tract requires a secure source of host-derived haem
Their common active ingredient, curcumin, can mediate mitophagy in OA chondrocytes by promoting AMPK/PINK1/Parkin, scavenging ROS, elevating mitochondrial membrane potential, and exerting an inhibitory effect on cartilage destruction (298)
