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En un estudio piloto temprano, bajo aplicacion topica de un complejo de cobre-tripeptido, 7 de 10 participantes mostraron un aumento de la sintesis de procolageno, frente a 5 de 10 con vitamina C y 4 de 10 con tretinoina (acido retinoico) como sustancias de referencia (Abdulghani et al., 199800011-4))

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The arginine substitution at position 3 and the N-terminal extension collectively reduce IGFBP affinity by approximately 1001,000-fold in preclinical binding assays

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